| 제목 | Weight change and resolution of fatty liver in normal weight individuals with nonalcoholic fatty liver disease | ||
|---|---|---|---|
| 작성자 | 관리자 | 등록일 | 2022-07-13 |
내용
Weight change and resolution of fatty liver in normal weight individuals with nonalcoholic fatty liver disease
Dong Hyun Sinn 1, Danbee Kang 2, Soo Jin Cho 3, Seung Woon Paik 1, Eliseo Guallar 4 5, Juhee Cho 2 4 5, Geum-Youn Gwak 1
Affiliations expand
- PMID: 33867441
- DOI: 10.1097/MEG.0000000000002158
Full text linksCite
Abstract
Objectives: Obesity is a well-known risk factor for nonalcoholic fatty liver disease (NAFLD), and weight reduction is primarily recommended for managing the disease. However, some NAFLD patients have a normal weight (lean NAFLD), and whether weight reduction is also recommendable for lean NAFLD patients remains unclear.
Methods: We conducted a longitudinal study of 16 738 adults (average age, 50.5 years; lean NAFLD, 2383 participants) with NAFLD at baseline who underwent repeated health check-up examinations, including bodyweight measurements and abdominal ultrasonography from January 2003 through December 2013.
Results: During 68 389 person-years of follow-up (median follow-up of 3.00 years), 5819 patients had a fatty liver resolution. Compared with participants who had no weight reduction or increased weight, the fully adjusted hazard ratios for fatty liver resolution in participants with 0-4.9, 5-9.9 and 10% or more weight reduction were 1.67 [95% confidence interval (CI), 1.57-1.77], 3.36 (95% CI, 3.09-3.65) and 5.50 (95% CI, 4.83-6.27), respectively. The association between weight reduction and the fatty liver resolution was stronger in overweight/obese NAFLD participants but was also evident in lean NAFLD participants in a dose-dependent manner. In spline regression models, the association between weight change and the fatty liver resolution was linear among participants with normal weight.
Conclusion: There was a dose-dependent association between weight reduction and fatty liver resolution in both lean and overweight/obese NAFLD patients. This finding suggests weight reduction as a primary recommendation for lean NAFLD patients as in overweight/obese NAFLD patients.
