Mirabegron has longer treatment persistence than antimuscarinics: Real-world data from a Korean national cohort database

Kyu-Sung Lee ¹, Hyejeong Park ¹, Danbee Kang ¹, Hye J Byun ², Chee Y Foo ³, Farid A Hadi ⁴, Soyoung Kim ⁴, Juhee Cho ⁵

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• PMID: 34486168
• DOI: 10.1002/nau.24776

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Abstract

Aims: To descriptively evaluate treatment persistence among adults who received mirabegron or antimuscarinics in South Korea.

Methods: This study involved a retrospective analysis of the Health Insurance Review and Assessment (HIRA) database. Patients (≥18 years) who had a new prescription for an overactive bladder (OAB) target medication (mirabegron/antimuscarinic) within an 8-month index period (July 1, 2015-February 29, 2016) were included. The date when the target (index) medication was dispensed was the index date. The 6-month period before the index date was used to assess patient eligibility. A 12-month post-index period was used to assess medication persistence, which was defined as the time to discontinuation. Overall data were analyzed and the results were also stratified by age group (≤65, >65 years), sex, or prior OAB medication experience. Persistence rates were calculated after the 1st, 3rd, 6th, 9th, and 12th months.

Results: A data set of 52 722 cases was obtained (mirabegron: 11 424, antimuscarinics: 41 298). The mean age was 60.9 ± 16.1 years and the majority of the patients were female (30 862 [58.5%] patients). Median persistence was longer with mirabegron (51 days) versus antimuscarinics (25 days). The persistence rate with mirabegron was higher throughout the study compared with all the antimuscarinics (12-month data: 13.5% and 4.9%, respectively). Longer treatment persistence was noted in older, male, and treatment-experienced patients.

Conclusion: The results from the HIRA database showed that persistence was longer with mirabegron than with antimuscarinics in South Korea. This finding may help inform clinical decision-making within the South Korean healthcare system. 

Keywords: South Korea; antimuscarinics; mirabegron; overactive bladder; persistence.