Association between Sarcopenia and Physical Function among Preoperative Lung Cancer Patients

Sunga Kong ^1 2, Sumin Shin ³, Jae Kyung Lee ², Genehee Lee ^1 2, Danbee Kang ^1 4, Juhee Cho ^1 4 5, Hong Kwan Kim ³, Jae Ill Zo ³, Young Mog Shim ³, Hye Yun Park ⁶, Dong Wook Shin ^7 8

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• PMID: 33066134
• PMCID: PMC7712435
• DOI: 10.3390/jpm10040166

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Abstract

We aimed to investigate the prevalence of sarcopenia using new diagnostic criteria and association of sarcopenia with cardiopulmonary function and physical activity (PA) in preoperative lung cancer patients. The data of 614 patients were obtained from the CATCH-LUNG cohort study. Patients were classified into three groups-normal (n = 520), pre-sarcopenia (n = 60, low skeletal muscle mass index only), and sarcopenia (n = 34, low SMI and strength). Cardiopulmonary function was measured using the 6-min walk test (6MWT), and PA was objectively measured using a wearable device. The adjusted odds ratio (aOR) for a <400-m distance in 6MWT was 3.52 (95% confidence interval (CI) 1.34-9.21) and 6.63 (95% CI 2.25-19.60) in the pre-sarcopenia and sarcopenia groups, respectively, compared to that in the normal group. The aOR (95% CI) for <5000 steps/day was 1.64 (0.65-4.16) and 4.20 (1.55-11.38) in the pre-sarcopenia and sarcopenia groups, respectively, compared to that in the normal group. In conclusion, the prevalence of pre-sarcopenia and sarcopenia was 9.8% and 5.5%, respectively, among preoperative lung cancer patients. Cardiopulmonary function and physical activity were significantly lower in the pre-sarcopenia and sarcopenia groups than in the normal group. Patients with sarcopenia had more robust findings, suggesting the importance of muscle strength and mass.

Keywords: cardiopulmonary function; lung cancer; muscle strength; physical activity; preoperative; sarcopenia; skeletal muscle mass.