삼성서울병원

Ko En

소아청소년과 최연호 교수

진료분야
크론병, 궤양성 대장염, 복통, 구토, 변비, 설사, 혈변, 헬리코박터 감염, 거대결장, 황달, 간염, 간이식, 소아영양, 소아내시경
진료일정 04 月
날짜
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오전
오후
진료일정 05 月
날짜
01
02
03
04
05
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07
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오전
오후

학력

학력
1999.02 서울대학교 대학원 의학과 (박사)
1992.02 서울대학교 대학원 의학과 (석사)
1988.02 서울대학교 의과대학 졸업 (의학사)

경력

경력
2019.01 ~현재 대한민국의학한림원 정회원
2018.0101 ~현재 성균관대학교 의과대학 학장
2001.03 ~현재 성균관의과대학 교수
2001.03 ~현재 영양관리위원회 위원
2016.0101 ~ 2017.12 성균관대학교 의과대학 교무부학장
2012.1101 ~ 2016.01 삼성서울병원 환자행복추진실 차장/Happy spirit 팀장
2011.0201 ~ 2015.12 성균관대학교 의과대학 교육부학장
2010.01 ~ 2011.12 삼성국제진료센터기획단 신규사업팀장
2009.09 ~ 2011.08 삼성서울병원 홍보실 실차장
2004.08 ~ 2005.08 미 UCLA, Dept. of Membrane Physiology 연수
1996.03 ~ 2001.02 인하대학병원 소아과 전임강사 및 조교수
1995.05 ~ 1996.02 서울대병원 소아과 소화기영양 전임의
1992.04 ~ 1995.04 육군(군의관)
1989.03 ~ 1992.02 서울대학병원 소아과 전공의
1988.03 ~ 1989.02 서울대학병원 인턴

연구분야

연구분야
소아청소년 크론병 특이 phenotyping에 따른 SNP 분석과 개인별 맞춤치료
소아청소년기에 나타나는 크론병과 궤양성대장염은 현재 전세계적으로 매우 급격히 발생율이 늘고 있다. 삼성서울병원 소아청소년과에서는 우리나라 최초로 소아청소년 크론병 및 궤양성 대장염 클리닉을 개설했고 환자의 증상별 맞춤치료 특히 면역억제제와 생물학적 주사제를 조기에 도입하여 매우 좋은 치료 성공율을 보이고 있다. 현재 이 분야에 대해 우리나라 소아청소년과에서 가장 업데이트된 치료법과 양질의 SCI 연구논문을 보유하고 있으며 향후 지속적으로 아래와 같은 연구를 수행할 예정이다. 1) 크론병 특이 phenotyping에 따른 SNP 분석 2) Infliximab의 top down strategy의 우월성 확인 3) Infliximab과 VSL#3의 병용치료에 대한 장기추적 조사 4) Infliximab 투여 후 2주 ESR이 장기 예후에 미치는 영향 조사

학회활동

학회활동
2013.10 ~ 2015.10 대한소아소화기영양학회 학술이사
2007.03 ~ 2012.12 대한헬리코박터 및 상부위장관 연구학회 학술위원
2005.10 ~ 2007.09 대한소아소화기 영양학회 재무이사
  • INDIAN PEDIATR 2019 10.1007/s13312-019-1649-5 Correlation of Dickkopf-1 with Inflammation in Crohn Disease Kim1, MJ; Choe, YH
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  • GUT LIVER 2019 10.5009/gnl18129 Serum Infliximab Cutoff trough Level Values for Maintaining Hematological Remission in Pediatric Inflammatory Bowel Disease Choi1, SY; Kang, B; Choe, YH
    View PubMed
  • J CROHNS COLITIS 2019 10.1093/ecco-jcc/jjy155 Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn's Disease Kang1, B; Choi, SY; Choi, YO; Lee, SY; Baek, SY; Sohn, I; Choe, BH; Lee, HJ; Choe, YH
    View PubMed
  • J CROHNS COLITIS 2018 10.1093/ecco-jcc/jjy021 Subtherapeutic Infliximab Trough Levels and Complete Mucosal Healing Are Associated With Sustained Clinical Remission After Infliximab Cessation in Paediatric-onset Crohn's Disease Patients Treated With Combined Immunosuppressive Therapy Kang1, B; Choi, SY; Choi, YO; Kim, MJ; Kim, K; Lee, JH; Choe, YH
    View PubMed
  • GUT LIVER 2018 10.5009/gnl17290 Early Infliximab Yields Superior Long-Term Effects on Linear Growth in Pediatric Crohn's Disease Patients Choi1, J; Kang, B; Kim, MJ; Sohn, I; Lee, HJ; Choe, YH
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  • EUR RADIOL 2018 10.1007/s00330-017-5092-5 Early US findings of biliary atresia in infants younger than 30 days Hwang1, SM; Jeon, TY; Yoo, SY; Choe, YH; Lee, SK; Kim, JH
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  • INFLAMM BOWEL DIS 2018 10.1093/ibd/izx047 Long-term Outcomes After Switching to CT-P13 in Pediatric-Onset Inflammatory Bowel Disease: A Single-Center Prospective Observational Study Kang1, B; Lee, Y; Lee, K; Choi, YO; Choe, YH
    View PubMed
  • BRIT J RADIOL 2017 10.1259/bjr.20170406 Imaging findings of Alagille syndrome in young infants: differentiation from biliary atresia Han1, S; Jeon, TY; Hwang, SM; Yoo, SY; Choe, YH; Lee, SK; Kim, JH
    View PubMed
  • Pharmacogenet Genomics. 2017 May;27(5):197-200. doi: 10.1097/FPC.0000000000000274. NUDT15 genotype distributions in the Korean population Kim HT11, Choi R, Won HH, Choe YH, Kang B, Lee K, Koo HH, Yoo KH, Kim YH, Lee SY.
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  • Ann Lab Med. 2017 May;37(3):261-266. doi: 10.3343/alm.2017.37.3.261. Novel SLC37A4 Mutations in Korean Patients With Glycogen Storage Disease lb Choi R11, Park HD2, Ko JM3, Lee J4, Lee DH4, Hong SJ5, Ki CS1, Lee SY1, Kim JW1, Song J6, Choe YH7.
    View PubMed
  • J Pediatr Gastroenterol Nutr. 2017 Feb;64(2):279-285. doi: 10.1097/MPG.0000000000001222. Baseline Wall Thickness Is Lower in Mucosa-Healed Segments 1 Year After Infliximab in Pediatric Crohn Disease Patients Kang B11, Choi SY, Chi S, Lim Y, Jeon TY, Choe YH.
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  • Gut Liver. 2017 Jan 15;11(1):55-61. doi: 10.5009/gnl16041. Clinical Use of Measuring Trough Levels and Antibodies against Infliximab in Patients with Pediatric Inflammatory Bowel Disease Choi SY11, Kang B1, Lee JH2, Choe YH1.
    View PubMed
  • J Crohns Colitis. 2016 Nov;10(11):1279-1286. Epub 2016 Apr 19. Mucosal Healing in Paediatric Patients with Moderate-to-Severe Luminal Crohn's Disease Under Combined Immunosuppression: Escalation versus Early Treatment Kang B11, Choi SY1, Kim HS2, Kim K2, Lee YM3, Choe YH4.
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  • PLoS One. 2016 Jun 24;11(6):e0158132. doi: 10.1371/journal.pone.0158132. eCollection 2016. Incremental Value of MR Cholangiopancreatography in Diagnosis of Biliary Atresia Sung S11, Jeon TY1, Yoo SY1, Hwang SM1, Choi YH2, Kim WS2, Choe YH3, Kim JH1.
    View PubMed
  • BMC Med Genet. 2016 Apr 21;17:33. doi: 10.1186/s12881-016-0295-1. PHKA2 mutation spectrum in Korean patients with glycogen storage disease type IX: prevalence of deletion mutations Choi R11, Park HD2, Kang B3, Choi SY3, Ki CS1, Lee SY1, Kim JW1, Song J4, Choe YH5.
    View PubMed
  • PLoS One. 2016 Feb 22;11(2):e0149681. doi: 10.1371/journal.pone.0149681. eCollection 2016. Alagille Syndrome Candidates for Liver Transplantation: Differentiation from End-Stage Biliary Atresia Using Preoperative CT Hwang SM11, Jeon TY1, Yoo SY1, Kim JH1, Kang B2, Choe YH2, Cho H3, Kim JS3.
    View PubMed
  • Liver Transpl. 2016 Feb;22(2):247-51. doi: 10.1002/lt.24372. De novo hepatitis b prophylaxis with hepatitis B virus vaccine and hepatitis B immunoglobulin in pediatric recipients of core antibody-positive livers Lee S11, Kim JM1, Choi GS1, Park JB1, Kwon CH1, Choe YH2, Joh JW1, Lee SK1.
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  • Inflamm Bowel Dis. 2015 Dec;21(12):2897-908. doi: 10.1097/MIB.0000000000000570. Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine Lee MN11, Kang B, Choi SY, Kim MJ, Woo SY, Kim JW, Choe YH, Lee SY.
    View PubMed
  • JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, SEP 2015, 61(3):E15-E15 Infliximab More Effective in Therapy-Naive Than in Therapy-Refractory Patients Response Kang B1, Choe YH,
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  • Transpl Int. 2015 Jul;28(7):835-40. doi: 10.1111/tri.12550. Epub 2015 Mar 13. Sustained linear growth and preserved renal function in 10-year survivors of pediatric liver transplantation Lee S11, Kim JM1, Choi GS1, Kwon CH1, Choe YH2, Joh JW1, Lee SK1.
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  • J Pediatr Gastroenterol Nutr. 2015 Jun;60(6):819-24. doi: 10.1097/MPG.0000000000000707. Sensory Processing Difficulties in Toddlers With Nonorganic Failure-to-Thrive and Feeding Problems Yi SH11, Joung YS, Choe YH, Kim EH, Kwon JY.
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  • J Pediatr Gastroenterol Nutr. 2015 Jun;60(6):737-43. doi: 10.1097/MPG.0000000000000711. Infliximab "Top-Down" Strategy is Superior to "Step-Up" in Maintaining Long-Term Remission in the Treatment of Pediatric Crohn Disease Lee YM11, Kang B, Lee Y, Kim MJ, Choe YH.
    View PubMed
  • Gut Liver. 2015 May 23;9(3):370-80. doi: 10.5009/gnl13408. Expression of TIM-3, Human beta-defensin-2, and FOXP3 and Correlation with Disease Activity in Pediatric Crohn's Disease with Infliximab Therapy Kim MJ11, Lee WY2, Choe YH3.
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  • Inflamm Bowel Dis. 2015 May;21(5):1054-62. doi: 10.1097/MIB.0000000000000347. Relationship Between Azathioprine Dosage, 6-Thioguanine Nucleotide Levels, and Therapeutic Response in Pediatric Patients with IBD Treated with Azathioprine Lee MN11, Kang B, Choi SY, Kim MJ, Woo SY, Kim JW, Choe YH, Lee SY.
    View PubMed
  • Pharmacogenet Genomics. 2015 Mar;25(3):143-6. doi: 10.1097/FPC.0000000000000117. Complete sequence-based screening of TPMT variants in the Korean population Kim HY11, Lee SH, Lee MN, Kim JW, Kim YH, Kim MJ, Lee YM, Kang B, Choe YH, Lee NH, Kim DH, Yoo KH, Sung KW, Lee SY, Koo HH.
    View PubMed
  • Clin Chim Acta. 2014 Nov 1;437:101-2. doi: 10.1016/j.cca.2014.07.011. Epub 2014 Jul 15. Safe azathioprine treatment in a pediatric ulcerative colitis patient with TPMT*16 by thiopurine metabolite monitoring Kim HY11, Kim JW1, Kim MJ2, Lee YM2, Kang B2, Choe YH3, Lee SY4.
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  • Yonsei Med J. 2014 Sep;55(5):1289-96. doi: 10.3349/ymj.2014.55.5.1289. Monitoring Thiopurine Metabolites in Korean Pediatric Patients with Inflammatory Bowel Disease Kim MJ11, Lee SY2, Choe YH3.
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  • Yonsei Med J. 2013 Nov;54(6):1545-9. doi: 10.3349/ymj.2013.54.6.1545. Successful Azathioprine Treatment with Metabolite Monitoring in a Pediatric Inflammatory Bowel Disease Patient Homozygous for TPMT*3C Lee MN11, Woo HI, Lee YM, Kang B, Kim JW, Choe YH, Lee SY.
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  • Pediatr Transplant. 2013 May;17(3):251-5. doi: 10.1111/petr.12051. Epub 2013 Feb 13. Long-term follow-up of de novo allergy in pediatric liver transplantation 10yr experience of a single center Lee Y11, Lee YM, Kim MJ, Lee SK, Choe YH.
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  • Indian Pediatr. 2012 Dec;49(12):979-82. Epub 2012 Jun 10. Effect of infliximab 'Top-down' therapy on weight gain in pediatric Crohn's disease Kim MJ11, Lee WY, Choi KE, Choe YH.
    View PubMed
  • Digestion. 2012;85(3):179-84. doi: 10.1159/000327909. Epub 2012 Jan 13. Effects of Proton Pump Inhibitors on Pediatric Inflammatory Esophagogastric Polyps Choi KE11, Kim MJ, Lee JH, Lee JS, Lee JH, Choe YH.
    View PubMed
  • J Autoimmun. 2012 Feb;38(1):49-58. doi: 10.1016/j.jaut.2011.12.009. Epub 2012 Jan 20. Demethylation analysis of the FOXP3 locus shows quantitative defects of regulatory T cells in IPEX-like syndrome Barzaghi F11, Passerini L, Gambineri E, Ciullini Mannurita S, Cornu T, Kang ES, Choe YH, Cancrini C, Corrente S, Ciccocioppo R, Cecconi M, Zuin G, Discepolo V, Sartirana C, Schmidtko J, Ikinciogullari A, Ambrosi A, Roncarolo MG, Olek S, Bacchetta R.
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  • Indian Pediatr. 2011 Dec;48(12):969-71. Azathioprine Hypersensitivity Presenting as Sweet Syndrome in a Child with Ulcerative Colitis Kim MJ11, Jang KT, Choe YH.
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  • Ann Clin Lab Sci. 2011 Spring;41(2):197-200. A novel PHKA2 gross deletion mutation in a Korean patient with X-linked liver glycogenosis type I Park KJ11, Park HD, Lee SY, Ki CS, Choe YH.
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  • Pediatr Emerg Care. 2011 Apr;27(4):284-9. doi: 10.1097/PEC.0b013e318213131a. Initial Location Determines Spontaneous Passage of Foreign Bodies From the Gastrointestinal Tract in Children Lee JH11, Lee JS, Kim MJ, Choe YH.
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  • J Pediatr Gastroenterol Nutr. 2011 Mar;52(3):314-8. doi: 10.1097/MPG.0b013e3181ebfa01. Norovirus: A Possible Cause of Pneumatosis Intestinalis Kim MJ11, Kim YJ, Lee JH, Lee JS, Kim JH, Cheon DS, Jeong HS, Koo HH, Sung KW, Yoo KH, Choe YH.
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  • Yonsei Med J. 2011 Mar;52(2):263-7. doi: 10.3349/ymj.2011.52.2.263. Changes in Glycogen and Glycosaminoglycan Levels in Hepatocytes of Iduronate-2-Sulfatase Knockout Mice before and after Recombinant Iduronate-2-Sulfatase Supplementation Lee JH11, Choe YH, Kim SJ, Paik KH, Jin DK.
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  • Acta Paediatr. 2011 Mar;100(3):451-5. doi: 10.1111/j.1651-2227.2010.01938.x. Infliximab therapy in children with Crohn's disease: a one-year evaluation of efficacy comparing 'top-down' and 'step-up' strategies Kim MJ11, Lee JS, Lee JH, Kim JY, Choe YH.
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  • Yonsei Med J. 2011 Mar;52(2):257-62. doi: 10.3349/ymj.2011.52.2.257. Delayed Response of Amylin Levels after an Oral Glucose Challenge in Children with Prader-Willi Syndrome Lee HJ11, Choe YH, Lee JH, Sohn YB, Kim SJ, Park SW, Son JS, Kim SW, Jin DK.
    View PubMed
  • Arch Dis Child. 2011 Jan;96(1):9-13. doi: 10.1136/adc.2010.188565. Epub 2010 Sep 23. The effects of three alternative treatment strategies after 8 weeks of proton pump inhibitor therapy for GERD in children Lee JH11, Kim MJ, Lee JS, Choe YH.
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  • Eur J Pediatr. 2010 Dec;169(12):1439-44. doi: 10.1007/s00431-010-1201-z. Epub 2010 May 6. EPONYM Sweet syndrome Kim MJ11, Choe YH.
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  • Childs Nerv Syst. 2010 Nov;26(11):1647-52. doi: 10.1007/s00381-010-1196-9. Epub 2010 Jun 22. Castleman's disease associated with a cerebellar chordoid meningioma and intestinal lymphangiectasia Jeon CJ11, Kim MJ, Lee JS, Lee JH, Kong DS, Shin HJ, Suh YL, Kim KM, Choe YH.
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  • Gut Liver. 2010 Sep;4(3):326-31. doi: 10.5009/gnl.2010.4.3.326. Epub 2010 Sep 24. Is Colonoscopy Necessary in Children Suspected of Having Colonic Polyps Lee HJ11, Lee JH, Lee JS, Choe YH.
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  • World J Gastroenterol. 2010 Apr 14;16(14):1776-81. Efficacy of early treatment with infliximab in pediatric Crohn's disease Lee JS11, Lee JH, Lee JH, Lee HJ, Kim MJ, Lee HJ, Choe YH.
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  • Yonsei Med J. 2010 Mar;51(2):202-5. doi: 10.3349/ymj.2010.51.2.202. Epub 2010 Feb 12. A Single Center Experience of Self-Bougienage on Stricture Recurrence after Surgery for Corrosive Esophageal Strictures in Children Lee HJ11, Lee JH, Seo JM, Lee SK, Choe YH.
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  • The Smith-Lemli-Opitz syndrome with a G303R/R352W mutation: in an extremely irritable child responsive to cholesterol supplementation
  • Yonsei Med J. 2010 Jan;51(1):39-44. doi: 10.3349/ymj.2010.51.1.39. Epub 2009 Dec 29. Helicobacter pylori Urease Activity is Influenced by Ferric Uptake Regulator Lee JS11, Choe YH, Lee JH, Lee HJ, Lee JH, Choi YO.
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  • Yonsei Med J. 2009 Dec 31;50(6):784-8. doi: 10.3349/ymj.2009.50.6.784. Epub 2009 Dec 18. Withdrawal of Immunosuppression in Pediatric Liver Transplant Recipients in Korea Lee JH11, Lee SK, Lee HJ, Seo JM, Joh JW, Kim SJ, Kwon CH, Choe YH.
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  • Helicobacter. 2009 Feb;14(1):36-9. doi: 10.1111/j.1523-5378.2009.00658.x. The Expression of Iron-repressible Outer Membrane Proteins in Helicobacter pylori and Its Association with Iron Deficiency Anemia Lee JH11, Choe YH, Choi YO.
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  • Gut Liver. 2007 Dec;1(2):132-7. doi: 10.5009/gnl.2007.1.2.132. Epub 2007 Dec 31. Ghrelin Levels in Gastric Mucosa before and after Eradication of Helicobacter pylori Choe YH11, Lee JH, Lee HJ, Paik KH, Jin DK, Song SY, Lee JH.
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  • Acta Paediatr. 2007 Dec;96(12):1784-9. Epub 2007 Oct 22. Allergic proctitis and abdominal distention mimicking Hirschsprung's disease in infants Lee JH11, Choe YH, Lee SK, Seo JM, Kim JH, Suh YL.
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  • Pediatr Transplant. 2007 Aug;11(5):518-23. The development of eosinophilic colitis after liver transplantation in children Lee JH11, Park HY, Choe YH, Lee SK, Lee SI.
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  • J Korean Med Sci. 2006 Dec;21(6):1037-40. Efficacy of two triple eradication regimens in children with Helicobacter pylori infection Choi J11, Jang JY, Kim JS, Park HY, Choe YH, Kim KM.
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  • Proteomics. 2006 Feb;6(4):1319-28. Comparative proteomic analysis of Helicobacter pylori strains associated with iron deficiency anemia Park SA11, Lee HW, Hong MH, Choi YW, Choe YH, Ahn BY, Cho YJ, Kim DS, Lee NG.
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  • J Clin Endocrinol Metab. 2005 Sep;90(9):5441-5. Epub 2005 Jun 14. Increased density of ghrelin-expressing cells in the gastric fundus and body in Prader-Willi syndrome Choe YH11, Song SY, Paik KH, Oh YJ, Chu SH, Yeo SH, Kwon EK, Kim EM, Rha MY, Jin DK.
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  • 없음 Sequencing and comparative analysis of napA genes from Helicobacter pylori strains associated with iron-deficiency anemia
  • J Clin Endocrinol Metab. 2005 Jun;90(6):3367-70. Epub 2005 Jan 18. Hyperghrelinemia does not accelerate gastric emptying in Prader-Willi syndrome patients Choe YH11, Jin DK, Kim SE, Song SY, Paik KH, Park HY, Oh YJ, Kim AH, Kim JS, Kim CW, Chu SH, Kwon EK, Lee KH.
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  • Eur J Pediatr. 2004 Oct;163(10):630-1; discussion 632-3. The infrequent bowel movements in young infants who are exclusively breast-fed Choe YH11, Lee JE, Moon KB, Hwang JH, Seo JM.
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  • Helicobacter. 2004 Aug;9(4):330-4. Polymorphism of the Helicobacter pylori feoB Gene in Korea: a Possible Relation with Iron-Deficiency Anemia Jeon BH11, Oh YJ, Lee NG, Choe YH.
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  • Proteomics. 2004 Jul;4(7):2014-27. Proteomic analysis of a ferric uptake regulator mutant of Helicobacter pylori: Regulation of Helicobacter pylori gene expression by ferric uptake regulator and iron Lee HW11, Choe YH, Kim DK, Jung SY, Lee NG.
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  • J Gastroenterol. 2004;39(3):231-7. Histopathology and expression of Ki-67 and cyclooxygenase-2 in childhood Helicobacter pylori gastritis Kim KM11, Oh YL, Ko JS, Choe YH, Seo JK.
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  • Helicobacter. 2004 Feb;9(1):54-8. Genotypes of the Helicobacter pylori vacA signal sequence differ with age in Korea Lee JH11, Choe YH, Jeon BH, Oh YJ, Kim JJ, Rhee JC, Kim PS, Choi MS.
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  • J Gastroenterol Hepatol. 2003 Aug;18(8):980-5. Lactoferrin sequestration and its contribution to iron-deficiency anemia in Helicobacter pylori-infected gastric mucosa Choe YH11, Oh YJ, Lee NG, Imoto I, Adachi Y, Toyoda N, Gabazza EC.
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  • Arch Dis Child. 2003 Feb;88(2):178. The relationship between Helicobacter pylori infection and iron deficiency: seroprevalence study in 937 pubescent children Choe YH1, Kim SK, Hong YC.
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  • Yonsei Med J. 2002 Jun;43(3):351-6. Diverse vacA allelic types of Helicobacter pylori in Korea and clinical correlation Choe YH11, Kim PS, Lee DH, Kim HK, Kim YS, Shin YW, Hwang TS, Kim HJ, Song SU, Choi MS.
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  • J Gastroenterol Hepatol. 2002 Feb;17(2):131-4. Higher seroprevalence of Helicobacter pylori infection in Korean adolescent athletes compared to age- and sex-matched non-athletes Choe YH11, Hwang tS, Hong YC.
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  • J Pediatr. 2001 Jul;139(1):100-4. Helicobacter pylori-associated iron-deficiency anemia in adolescent female athletes Choe YH11, Kwon YS, Jung MK, Kang SK, Hwang TS, Hong YC.
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  • J Korean Med Sci. 2001 Jun;16(3):363-5. Restrictive cardiomyopathy in a patient with extrahepatic biliary atresia Jeong SJ11, Choe YH, Hong YJ.
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